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KMID : 0882420190940050455
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Korean Journal of Medicine
2019 Volume.94 No. 5 p.455 ~ p.458
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Mycophenolate Mofetil Overdose Induced Ventricular Tachycardia in a Patient with Systemic Lupus Erythematosus
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Kim Jung-Hun
Chung Hyun-Ji
Lee Kyung-Ann
Kim Hae-Rim
Lee Sang-Heon
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Abstract
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Mycophenolate mofetil (MMF) is an immunosuppressive agent used to treat severe lupus, including lupus nephritis. Common adverse effects of MMF include gastrointestinal and hematological manifestations; however, cardiac toxicity in association with MMF has not been reported. We present a 21-year-old woman with lupus nephritis who developed ventricular tachycardia 2 hours after an overdose of MMF (34 g). Ventricular bigeminy was documented 12 hours after the MMF overdose. Transthoracic echocardiography showed no evidence of structural heart disease. The ventricular arrhythmia was successfully treated with potassium replacement, hydration, and cholestyramine. This case suggests that an overdose of MMF can induce ventricular tachycardia, and electrocardiogram monitoring is critical to identify this rare cardiac complication of MMF.
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KEYWORD
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Mycophenolic acid, Tachycardia, Ventricular, Lupus erythematosus, Systemic
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